SHSY5Y assays proved that this compound acts as a Nrf2 activator leading to an improvement of antioxidant defenses. The antioxidant properties of makaluvamine J are related to an improvement of the endogenous antioxidant defenses of glutathione and catalase. This compound was able to reduce the mitochondrial damage elicited by the well-known stressor H 2O 2. ![]() Among the alkaloids studied, makaluvamine J was the most active in all the assays. In the present work, seven makaluvamines were tested in several antioxidant assays in primary cortical neurons and neuroblastoma cells. Until now, they have been described as topoisomerase II inhibitors with cytotoxic effects in diverse tumor cell lines. Makaluvamines are pyrroloiminoquinones isolated from Zyzzya sponges.
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